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Moreover, PGC-1α gain-of-function was shown to enhance RPE metabolic functions and resistance to oxidative stress through the induction of oxidative metabolic genes and antioxidant enzymes (Iacovelli et al, 2016).

Effects of different stressors on UPR activation at the proteome level. (A) Time course and dose-dependence of different stressors. HeLa cells were treated for 5 and 18 h as indicated with low (DTT 0.2 µM, thapsigargin 0.1 µm, tunicamycin 0…

For example, Notch EGF domain 8 plays a role in selective recognition of Serrate/Jagged and EGF domains 6-15 are required for maximal signaling upon ligand stimulation. A crystal structure of the interacting regions of Notch1 and Delta-like…

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